Dual Angle Static and Dynamic Light Scattering

Dual angle light scattering GPC/SEC/GFC detector for static light scattering and optional dynamic light scattering.

The MDS390 is an integrated 15° and 90° static light scattering detector for the measurement of absolute molecular weight of macromolecules in solution. It can be used with any type of GPC/SEC/GFC or FFF system.

The instrument can come with up to three detectors (light scattering, viscometry, RI) at once or can be field upgraded any time a new technique is required. Any detector combination is possible. Each MDS detector can be individually heated from 30 – 60 °C to ensure baseline stability. All detectors can be used in series, ensuring all of the analyte is studied.

A bioninert version supporting dual angle static and 90° dynamic light scattering is ideally suited for the analysis of biopolymers and proteins.

Universal applicability


Integrated Dual Angle LS Detector

  • Integrated static light scattering for the detection of the time-averaged scattering intensity at 15° and 90° detection angle.
  • optional dynamic light scattering for the determination of the hydrodynamic radius at 90° detection angle.
  • 660 nm/50 mW Light source.
  • various configurations matching all requirements, from LS only up to triple detection.
  • field upgrade options for viscometry and RI detection.

Connect to any LC

Connect to any LC

The MDS390 can be connected to virtually any LC.

Operation connected to a liquid chromatography system requires WinGPC UniChrom software for detector control, data acquisition and analysis. WinGPC can manage a variety of LC systems directly.

Systems without ChromPilot 3rd Party Control can be connected using either PSS data acquisition hardware or the 2 analog ins of the MDS390

Data analysis requires WinGPC UniChrom software with the multi angle light scattering module.

Software Options

Chromatography Data System with Light Scattering Analysis

Don't sacrifice flexibility, user-friendliness and compliance just to add light scattering to your lab. Protect your investments and ensure integrated solutions - now and in future.

When connecting to an LC use WinGPC UniChrom MultiWorkstation or Client/Server to control the detector and the LC, acquire data and allow for comprehensive manual or automated analysis with flexible result output. Software wizards and guided setups support users and facilitate learning.

  • Profit from the convenient, secure and continuously improved features of a world wide used Chromatography Data System equipped with specific light scattering data analysis routines and test procedures.
  • Automatically generate ultra-fast molar mass and size results including result uncertainty even within an active sequence.
  • Or analyze samples in all details using WinGPC's advanced features and sophisticated tools.   
  • Transfer all results to a LIMS, create extensive reports and provide clear, scalable figures for presentations - all within one software package.


 SLD2020SLD7100SLD1000MDS Dual Angle
Detector type20 angle simultaneous detection  (MALLS)7 angle simultaneous detection  (MALLS)1 angle, 90° (multicolor RALLS)2 angle (integrated, dual angle)
No. of angles20712
Detection angles/
scattering angles
12, 20, 28, 36, 44, 52, 60, 68, 76, 84, 90, 100, 108, 116, 124, 132, 140, 148, 156, 164
detection angle = scattering angle
35, 50, 75, 90 105, 130, 145
index-matching cell: detection angle = scattering angle
9015, 90
Cell/Cell volumeGlass, SST (standard), Titanium, PTFE + 25% carbon, 63 µL, vertical, self-cleaningPEEK, 100µL nominal
vertical, self-cleaning
analytical: 8µL cell
bioinert: 8µL cell
micro: 4µL cell
Scattering volume< 7.8 nL20 nL nominal 0.01µL
Laser wavelength/power120 mW, 660 nm, vertically polarized, temperature stabilized light source with precision power control635 nm/35 mW, vertically polarized,
temperature stabilized with precision power control
user selectable arbitrary wavelength between 300-600 nm,
can be changed within sequence
660 nm/50 mW
  • metal-free flow path (P/N 403-1018, SLD2020B)
  • fluorescence filter (Upgrade options: P/N 403-1024 (10 filter)/P/N 403-1025 (20 filter))
  • fluorescence filter (Initial: P/N 403-1021 (10 filter) / P/N 403-1022 (20 filter))
  • temperature control (P/N 403-0005)
  • metal-free flow path (P/N 403-0014, SLD7100B)
  • fluorescence filter (P/N 403-0011)
  • Software for operation in batch mode (P/N 403-0004)
  • µ-flow cell
  • bioinert flow cell
  • upgrade with viscometer and/or RI in same enclosure
  • upgrade with viscometer and/or RI, enclosure expansion
  • metal free flow path, optional: dynamic light scattering


Learn More

Webinar GPC/SEC- Light Scattering

Theoretical background, advantages and limitations? Learn more in this webcast.

e-book: GPC/SEC Detection

(Absolute) molar masses, structures, branching, composition - request our e-book on GPC/SEC detection.


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